Mohamed Rahmani Selected Research

2- (2- chloro- 4- iodophenylamino)- N- cyclopropylmethoxy- 3,4- difluorobenzamide

11/2009	The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways.
9/2008	Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.
4/2006	Synergistic interactions between DMAG and mitogen-activated protein kinase kinase 1/2 inhibitors in Bcr/abl+ leukemia cells sensitive and resistant to imatinib mesylate.
1/2002	Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells.

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Mohamed Rahmani Research Topics

Disease

39	Leukemia 01/2020 - 01/2002
24	Neoplasms (Cancer) 12/2021 - 10/2005
12	Mitochondrial Diseases (Mitochondrial Disease) 09/2008 - 01/2002
9	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2020 - 01/2006
7	Myeloid Leukemia (Leukemia, Myelocytic) 12/2015 - 01/2002
6	Melanoma (Melanoma, Malignant) 01/2019 - 06/2010
5	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 09/2007 - 07/2004
3	Carcinoma (Carcinomatosis) 06/2010 - 10/2008
3	Hematologic Neoplasms (Hematological Malignancy) 04/2006 - 11/2003
2	Adenocarcinoma 12/2021 - 09/2008
2	COVID-19 06/2021 - 01/2021
2	Breast Neoplasms (Breast Cancer) 01/2021 - 11/2009
2	Non-Hodgkin Lymphoma (Lymphosarcoma) 09/2019 - 05/2017
2	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 05/2017 - 09/2014
2	Ataxia Telangiectasia (Louis Bar Syndrome) 09/2015 - 04/2003
2	B-Cell Lymphoma (Lymphoma, B Cell) 07/2014 - 05/2009
2	Pancreatic Neoplasms (Pancreatic Cancer) 08/2009 - 09/2008
2	Multiple Myeloma 06/2005 - 04/2004
1	Colorectal Neoplasms (Colorectal Cancer) 12/2021
1	Liver Diseases (Liver Disease) 06/2021
1	Inflammation (Inflammations) 01/2020
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2020
1	Heart Failure 01/2019
1	Lymphoma (Lymphomas) 05/2017

Drug/Important Bio-Agent (IBA)

19	Histone Deacetylase InhibitorsIBA 09/2019 - 07/2002
18	Proteins (Proteins, Gene)FDA Link 12/2021 - 01/2002
10	CaspasesIBA 02/2013 - 09/2003
9	Imatinib Mesylate (Gleevec)FDA Link 09/2007 - 01/2002
9	Cytochromes c (Cytochrome c)IBA 08/2006 - 01/2002
9	Butyric Acid (Butanoic Acid)IBA 01/2006 - 07/2002
8	Sorafenib (BAY 43-9006)FDA Link 06/2012 - 10/2005
8	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2010 - 05/2004
8	Phosphotransferases (Kinase)IBA 05/2010 - 01/2002
8	Vorinostat FDA Link 08/2009 - 12/2003
7	CytokinesIBA 01/2021 - 06/2010
7	Bortezomib (Velcade)FDA Link 05/2017 - 10/2003
6	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 11/2009 - 09/2003
6	Proteasome InhibitorsIBA 05/2009 - 10/2003
6	Cyclin-Dependent Kinases (cdk Proteins)IBA 08/2006 - 04/2003
6	7-hydroxystaurosporine (UCN 01)IBA 06/2005 - 07/2002
5	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 05/2010 - 01/2002
5	tanespimycin (17AAG)IBA 05/2010 - 09/2003
5	Heat-Shock Proteins (Heat-Shock Protein)IBA 05/2010 - 09/2003
4	Histone Deacetylases (Histone Deacetylase)IBA 01/2016 - 11/2003
4	ABT-737IBA 12/2015 - 05/2011
4	CeramidesIBA 11/2010 - 03/2005
4	Mitogen-Activated Protein KinasesIBA 05/2010 - 01/2002
4	2- (2- chloro- 4- iodophenylamino)- N- cyclopropylmethoxy- 3,4- difluorobenzamideIBA 11/2009 - 01/2002
4	NF-kappa B (NF-kB)IBA 07/2005 - 09/2003
4	alvocidib (flavopiridol)IBA 10/2004 - 04/2003
3	EnzymesIBA 06/2021 - 12/2010
3	RNA (Ribonucleic Acid)IBA 06/2021 - 01/2020
3	InterleukinsIBA 05/2011 - 06/2010
3	Interleukin-10 (Interleukin 10)IBA 05/2011 - 06/2010
3	Pharmaceutical PreparationsIBA 05/2010 - 06/2005
3	CASP8 and FADD-Like Apoptosis Regulating Protein (FLIP-S)IBA 08/2009 - 09/2008
3	Caspase 3 (Caspase-3)IBA 04/2005 - 01/2002
2	belinostatIBA 05/2017 - 01/2016
2	dactolisibIBA 09/2014 - 02/2013
2	obatoclaxIBA 06/2012 - 11/2009
2	Peptide Initiation Factors (Initiation Factor)IBA 12/2010 - 08/2007
2	Small Interfering RNA (siRNA)IBA 12/2010 - 08/2004
2	Endoplasmic Reticulum Chaperone BiPIBA 12/2010 - 05/2010
2	geldanamycinIBA 05/2010 - 09/2008
2	Mitogen-Activated Protein Kinase 3IBA 11/2009 - 09/2008
2	perifosineIBA 11/2009 - 03/2005
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 11/2009 - 04/2003
2	U 0126 (UO 126)IBA 11/2009 - 04/2003
2	MAP Kinase Kinase 1IBA 09/2008 - 04/2006
2	p38 Mitogen-Activated Protein KinasesIBA 09/2008 - 04/2003
2	src-Family KinasesIBA 05/2007 - 08/2004
2	benzyloxycarbonylleucyl-leucyl-leucine aldehydeIBA 01/2006 - 10/2003
2	TyrphostinsIBA 01/2006 - 02/2004
2	NSC 680410IBA 01/2006 - 02/2004
2	entinostat (MS 275)IBA 07/2005 - 04/2004
2	Farnesyltranstransferase (Farnesyltransferase)IBA 06/2005 - 02/2005
2	Apoptosis Inducing FactorIBA 04/2005 - 03/2005
2	Sirolimus (Rapamycin)FDA Link 03/2005 - 04/2003
2	Protein Kinase CIBA 03/2005 - 09/2003
2	Caspase 8 (Caspase-8)IBA 02/2005 - 07/2002
2	AntioxidantsIBA 05/2004 - 02/2004
2	Acetylcysteine (Siran)FDA LinkGeneric 05/2004 - 02/2004
2	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 04/2004 - 01/2002
2	Proteasome Endopeptidase Complex (Proteasome)IBA 11/2003 - 10/2003
2	RoscovitineIBA 10/2003 - 04/2003
2	2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- oneIBA 09/2003 - 04/2003
2	MitogensIBA 04/2003 - 01/2002
1	Messenger RNA (mRNA)IBA 12/2021
1	Biomarkers (Surrogate Marker)IBA 12/2021
1	Progesterone Receptors (Progesterone Receptor)IBA 01/2021
1	venetoclaxIBA 01/2020
1	cobimetinibIBA 01/2020
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2019
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2019
1	Protein Isoforms (Isoforms)IBA 01/2019
1	Polo-Like Kinase 1IBA 05/2017

Therapy/Procedure

4	Therapeutics 01/2020 - 10/2011
1	Colectomy 12/2021
1	Lasers (Laser) 01/2021
1	Immunomodulation 01/2020